Nov 27, 2025 · Next-day grogginess from mirtazapine is common due to its antihistamine properties, which are stronger at lower doses. The effect typically lessens with time and is …

Dec 8, 2025 · Doctors recommend taking it at bedtime-ideally 30 to 60 minutes before sleep. That way, the peak sedation aligns with your natural sleep window. The FDA label confirms this: …

Oct 31, 2025 · That morning fog and heavy feeling are pretty common while your body adjusts. For me it slowly improved over a couple of weeks, though the first mornings were rough.

Sep 17, 2020 · I recently started taking mirtazapine and the groggy feeling was pretty bad for up to about 10 days, where I felt sleepy throughout the day. The sleepiness is wearing off now.

Nov 30, 2021 · My GI doc really wanted me to take Mirtazapine and I gave it a shot several times but it has made me sleep 12 hours a day every time I try, which simply isn’t sustainable, as I …

Jun 24, 2025 · In some cases, the drowsiness can last beyond the first few hours after taking mirtazapine. It’s almost as if your body is slowly unwinding from its daytime activities, lingering …

Jul 15, 2025 · For some people, the sleep-inducing effects of mirtazapine appear within one or two days after starting to take the drug. When used for depression, mirtazapine may take …