THIN-LAYER chromatography on cellulose layers has been shown to be an effective method for separation and quantitative determination of nucleic acid bases, nucleosides and nucleotides 1–5 which has ...

Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases. (Image: Wikimedia Commons, CC SA 3.0) The most common type of base pairing is the Watson-Crick base ...

DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast ...

Structural comparison of DNA and the artificial TNA, a Xeno nucleic acid with the natural base pairs AT and GC and an additional base pair (XY). The DNA carries the genetic information of all living ...

Peptide nucleic acids (PNAs) represent a revolutionary class of synthetic nucleic acid analogues, in which the traditional sugar–phosphate backbone is replaced by a neutral N-(2-aminoethyl) glycine ...

As a molecular biologist, I always enjoy reading articles concerning DNA and RNA. Your excellent article in the April 3, 2023, issue of C&EN (page 18) titled “The Promise of Peptide Nucleic Acids” ...

The primary bottleneck in this procedure is the inability to culture forensically relevant pathogens under laboratory conditions; moreover, nucleic acids may be low quality or damaged, rendering them ...

Origin-of-life researchers face a deceptively straightforward question: how did simple chemicals produce complex biochemistry? The complexity of this starts to come in when you consider the many ...

Three free radicals have been detected in single crystals of a molecular complex between 1-methylcytosine (1MeC) and 5-fluorouracil (5FU) X-irradiated and observed by ESR at 77 K. One of these ...

A researcher is developing a patent-pending platform technology called LENN that mimics the dual-layer structure of viruses to deliver nucleic acid (NA)-based therapies to targeted cancer cells. A ...

When planet Earth was still in its infancy, the precursor of life may have self-replicating strands of RNA. Indeed, scientists presume that this "RNA world" laid the foundation for everything we see ...