In reading, a bookmark tells where you stopped. Cells use bookmarks too, specific proteins that help the cell remember what collection of genes needs to be turned on again after the brief halt of gene ...

In summary, macrophages secrete IFN-β, activating the IFN-β-IFNAR-p-STAT1 axis in MICFs, leading to increased secretion of CCL2/7/12 chemokines and subsequent recruitment of more IFN-β-secreting ...

The research uncovers a previously unappreciated mechanism by which macrophages influence the fate of CFs post-MI. It demonstrates that macrophage-derived IFN-β stimulates the IFN-β-IFNAR-p-STAT1 axis ...

Metabolic reprogramming in fibrotic lung diseases involves key metabolites like lactate, succinate, and 2-hydroxyglutarate, driving inflammation and fibroblast activation. Lactate accumulation ...

Background Intestinal fibrosis, a hallmark complication of Crohn’s disease (CD), frequently progresses to stricture formation ...

In laboratory experiments, G.V. Shivashankar and his team were able to significantly speed up the regeneration and wound healing of skin tissue using stem-cell-like fibroblasts. Researchers at PSI and ...

Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells. Scientists ...

Mitochondrial transfer is known to occur from the tumor microenvironment into cancer cells, but now, Swiss researchers have shown a possible precursor to this is that cancer cells smuggle their ...

Jonas Salk quietly built the polio vaccine through rigorous, methodical work in Pittsburgh: treating patients, refinin ...

(Nanowerk News) Researchers at PSI and ETH Zurich have taken connective tissue cells that have been mechanically reprogrammed to resemble stem cells and transplanted them into damaged skin. In their ...